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[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Knudsen L.B., Secher A., Hecksher-Srensen J., Pyke C

"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky

However, each additional compound adds variables

Squire, P., Naude, J., Zentner, A., Bittman, J